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Harsh pH High-pH pouches hit fast, but the burn, irritation, and gum issues are things youre expected to tolerate if you want nicotine

We think that while it is clear that different endpoints may yield quite different results, the human MOE for cannabis based on the endpoint psychotropic effects can be seen as general validation of the MOE concept, because the resulting values below 1 are expected as the psychotropic effect is the desired endpoint (and hence the psychotropic threshold dose is exceeded by drug users)

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Lets get this straight neither is 100% risk-free